Nava Applebaum was the eldest daughter of David and Debra Applebaum, the third of six children. Her father, David Applebaum, was a prominent emergency room doctor well-known for work on methods for assisting suicide bombing victims. He was born in Detroit, Michigan, and moved to Chicago, Illinois, as a teenager. After being ordained as a rabbi, he attended Northwestern University and graduated with a Masters in Biology, before attending the University of Toledo Medical Center. He moved to Israel in 1982, and traveled back at times to practice in the United States.
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